ML 604440

Research use only, not for human use.

ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.

ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor; reduces the cleavage of Ac-PAL-AMC by proteasomes from WT mice in a dose-dependent manner (12.5-200 nM), with no affect on β5/LMP7.

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Animal Model:Male C57BL/6J mice (6-8-wks old) injected with anti-platelet monoclonal antibody Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg; once daily; 7 days Result:Inhibited LMP2 in vivo.Showed no significant improvement in platelet counts in mice immunized by monoclonal rat anti-mouse CD41 platelet antibody.

ML604440 | ML-604440

Proteasome/Ubiquitin

Proteasome

Proteasome

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1140517-08-3

388.194

C17H24BF3N2O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (257.61 mM)

CC(C)C[C@@H](B(O)O)NC(C(NC(C1=CC=CC=C1C(F)(F)F)=O)(C)C)=O

(R)-(3-methyl-1-(2-methyl-2-(2-(trifluoromethyl)benzamido)propanamido)butyl)boronic acid

(-20℃)

With Ice Pack

≥ 2 years